gb88An important finding has been reported that GB88 inhibits the PAR2 activated Ca 2+ release, induced by trypsin or synthetic peptide in vitro (28). The GB88B ) PAR2 antagonist GB88 (1.6 Ϯ 0.5 M) was 1000-fold more potent than ENMD-1068 (1.2 Ϯ 0.4 mM) in preventing trypsin-induced intracellular calcium release ([Ca 2 ϩ ] i ) in HMDMs ( n ϭ